There are several actors and one actress from comic book movies and television shows: -Norman Reedus played Daryl Dixon in The Walking Dead (2010) and played Frank Castle/The Punisher in Iron Man: Rise of Technovore (2013). -Gal Gadot played Diana Prince/Wonder Woman in Batman v Superman: Dawn of Justice (2016), Wonder Woman (2017), Justice League (2017), Wonder Woman 1984 (2020), Zack Snyder's Justice League (2021), Wonder Woman 3 and Justice League Part Two. -Chiwetel Ejiofor played Baron Mordo in Doctor Strange (2016) and Doctor Strange in the Multiverse of Madness (2022). -Anthony Mackie played Sam Wilson/Falcon in Captain America: The Winter Soldier (2014), Avengers: Age of Ultron (2015), Ant-Man (2015), Captain America: Civil War (2016), Avengers: Infinity War (2018), Avengers: Endgame (2019) and The Falcon and the Winter Soldier (2021). -Woody Harrelson played Cletus Kasady in the post-ending credits of Venom (2018). Kasady is the alter ego for super-villain Carnage.
This is a prospectively designed study. Up to 229 newly diagnosed invasive HER2-positive or triple-negative breast cancer patients planning neoadjuvant therapy (NAT) will be enrolled. Blood samples will be collected pre-operatively at the time of diagnosis/prior to NAT, post-cycle 1/pre-cycle 2 of NAT, after all NAT/immediately before surgery, and post-operatively at 6, 12, 24, and 36 months, and annually thereafter if funding allows. Researchers will also collect representative tissue samples from the diagnostic biopsy (in all participants) and definitive surgery (if available). Additionally, to look at feasibility of tumor DNA analyses in urine samples, urine samples will be collected along with blood samples (urine tumor DNA or utDNA).
Triple 9 (2016)
To estimate the negative predictive value (NPV) of the absence of plasma tumor DNA (ptDNA) Tumor Specific Mutations (TSMs) after neoadjuvant therapy (NAT) for the absence of residual disease as defined by pathologic complete response (pCR) in stage II-III HER2-positive or triple negative breast cancer (TNBC) 2ff7e9595c
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